HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl D-alaninate → (R)-2-[(7-Benzyloxy-1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl D-alaninate | HCID 89020 | — |
| Reactant | 7-Benzyloxy-1-chloro-4-hydroxy-isoquinoline-3-carboxylic acid | HCID 18698130 | — |
| Product | (R)-2-[(7-Benzyloxy-1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-propionic acid methyl ester | HCID 86595455 | — |
Reaction Steps
7-Benzyloxy-1-chloro-4-hydroxy-isoquinoline-3-carboxylic acid, 0.33 g, was coupled with D-Alanine methyl ester analogously to Example A-1 a). 0.246 g of off-white solid were obtained: MS-(+)-ion, M+1=415.0 amu.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916585B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-4a7fb976c927449ca8aaad03f6190862 |
| Source note | uspto-grants-2014_12 |