L-Alanine → HCID 57423253, compound

HRID 1406110Notes

Reaction equation

HRID 1406110 reaction equation
C(O[C:6]([C:8]1[N:9]=[CH:10][C:11]2[C:16]([C:17]=1[OH:18])=[CH:15][CH:14]=[C:13]([O:19][C:20]1[CH:25]=[C:24]([O:26][CH3:27])[CH:23]=[C:22]([F:28])[CH:21]=1)[CH:12]=2)=[O:7])CCC.[NH2:29][C@H:30]([C:32]([OH:34])=[O:33])[CH3:31]>>[F:28][C:22]1[CH:21]=[C:20]([CH:25]=[C:24]([O:26][CH3:27])[CH:23]=1)[O:19][C:13]1[CH:12]=[C:11]2[C:16]([C:17]([OH:18])=[C:8]([C:6]([NH:29][C@@H:30]([CH3:31])[C:32]([OH:34])=[O:33])=[O:7])[N:9]=[CH:10]2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 5950L-AlanineHCID 66712537HCID 66712537, compound

Product 1

HCID 57423253HCID 57423253, compound

Procedure

Prepared in analogy to Example A-50 by reacting 7-(3-fluoro-5-methoxy-phenoxy)-4-hydroxy-isoquinoline-3-carboxylic acid butyl ester (compound of example A-73 a) with L-alanine in a pressure tube for 3 days at 90 C. MS-(−)-ion M−1=399.1.

Workup

  1. customfor 3 days

Sources & evidence

ORD record
ord-6b072dd3d412419ca582183c4dab08e0
Source dataset
uspto-grants-2014_12
Patent number
US08916585B2

Reaction notes

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