Glycine → HCID 66713178, compound

HRID 1406178Notes

Reaction equation

HRID 1406178 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([C:11]([OH:13])=O)[C:5](=[CH:9][CH:10]=1)[C:6]([OH:8])=O.[NH2:14][CH2:15][C:16]([OH:18])=[O:17]>>[I:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:9][CH:10]=1)[C:6](=[O:8])[N:14]([CH2:15][C:16]([OH:18])=[O:17])[C:11]2=[O:13]

Participants

3

Reactant 2

HCID 750GlycineHCID 805474-Iodophthalic acid

Product 1

HCID 66713178HCID 66713178, compound

Conditions

Temperature
200 °C

Procedure

4-Iodo-phthalic acid, 10 g, was mixed intimately with 2.63 g of glycine and the mixture was heated to 200° C. for 10 min. After cooling, the solid reaction mixture was extracted with ethyl acetate to give, after concentration, 6.40 g of tan solid: MS-(−)-ion, Proton NMR (200 MHz, methanol-d-4): δ 8.26-8.18 (m, 2H), 7.68-7.61 (m, 1H), 4.39 (s, 1 H).

Workup

  1. temperatureAfter cooling
  2. customthe solid reaction mixture
  3. extractionwas extracted with ethyl acetate
  4. customto give
  5. concentrationafter concentration, 6.40 g of tan solid

Sources & evidence

ORD record
ord-abffde7b1de44f3a82c9e0ffc3e2a327
Source dataset
uspto-grants-2014_12
Patent number
US08916585B2

Reaction notes

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