(alphaS)-2,5-Difluoro-alpha-methylbenzenemethanol → 5-Bromo-3-[(R)-1-(2,5-difluoro-phenyl)ethoxy]-2-nitro-pyridine

Participants

Reaction Steps

The title compound was prepared by a similar method to that of preparation 18 using commercially available 5-bromo-3-hydroxy-2-nitro-pyridine and (S)-1-(2,5-difluoro-phenyl)-ethanol except the reaction time was 1 hr and crude reaction purified by chromatography on silica gel eluting with ethyl acetate in heptane (50:50) to give a yellow oil (21.0 g, 93%).

Provenance & Evidence