2-Amino-5-bromo-3-hydroxypyridine → 5-Bromo-3-[1-(2-chloro5-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine

Participants

Reaction Steps

The title compound was prepared by a similar method to that of preparation 18 using commercially available 5-bromo-3-hydroxy-2-amino-pyridine and 1-(2-chloro-5-fluoro-phenyl)-ethanol (prepared according to WO 2009087305 A1) except the reaction time was 18 hr and the crude reaction was purified by chromatography on silica gel eluting initially with ethyl acetate in dichloromethane (2:98) followed by a second purification on silica gel eluting with tert-butyl methyl ether in heptane (45:55) to give a white solid (3.82 g, 49%).

Provenance & Evidence