Sodium borohydride → 1342978-00-0

HRID 1406294Notes

Reaction equation

HRID 1406294 reaction equation
[CH2:1]([C:3]1[N:4]=[C:5]([C:8](OCC)=[O:9])[S:6][CH:7]=1)[CH3:2].[BH4-].[Na+]>CO>[CH2:1]([C:3]1[N:4]=[C:5]([CH2:8][OH:9])[S:6][CH:7]=1)[CH3:2]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 62040440HCID 62040440, compound

Product 1

HCID 587670591342978-00-0Yield 107.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 4-ethylthiazole-2-carboxylate (500 mg 2.27 mmol) was stirred in methanol (20 mL) under nitrogen. Sodium borohydride (230 mg 6.07 mmol) was added in portions and the resulting solution stirred for a further 3 hours. The methanol was removed under vacuum and the residue dissolved in ethyl acetate (40 mL), washed with water, dried over sodium sulfate and concentrated to give the title product as a colorless oil (350 mg, 91%).

Workup

  1. customThe methanol was removed under vacuum
  2. dissolutionthe residue dissolved in ethyl acetate (40 mL)
  3. washwashed with water
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-8f167c977bd24f50ac0ca5a5a32b760a
Source dataset
uspto-grants-2014_12
Patent number
US08916593B2

Reaction notes

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