4-Bromo-1-(bromomethyl)-2-(methanesulfonyl)benzene → (4-Bromo-2-methanesulfonyl-benzyl)-methyl-amine

Participants

Reaction Steps

A solution of 4-bromo-1-bromomethyl-2-methanesulfonyl-benzene (300 mg, 0.9 mmol) in ˜40% MeNH2/MeOH (10 mL) was stirred at room temperature for 3 hours. TLC (petroleum ether:EtOAc 3:1) showed the reaction was complete. The reaction mixture was concentrated in vacuo to give crude title compound (200 mg, 80%) as a yellow oil, which was used for next step without further purification.

Provenance & Evidence