Thionyl Chloride → HCID 67467008, compound

Participants

Reaction Steps

To a solution of (5-bromo-4-ethylthiazol-2-yl)methanol (313 mg 1.41 mmol) in THF (15 ml) under nitrogen at room temperature was added thionyl chloride (0.206 ml 2.82 mmol) and stirred overnight. LCMS indicated the completion of the reaction. A saturated ice cold aqueous NaHCO3 solution was added to the reaction solution with gas evolution. The mixture was extracted with EtOAc (4×20 ml), dried over sodium sulfate and concentrated to give a brown oil 301 mg, 89% which was used for the next step without further purification.

Provenance & Evidence