HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 4-(4-Bromo-2-chloro-phenoxy)-benzylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 4-(4-Bromo-2-chloro-phenoxy)-benzaldehyde-oxime | HCID 86658818 | — |
| Catalyst | Dichloronickel;hexahydrate | HCID 11791229 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(4-Bromo-2-chloro-phenoxy)-benzylamine | HCID 28966390 | — |
Reaction Steps
18 mg (0.06 mmol) of 4-(4-bromo-2-chloro-phenoxy)-benzaldehyde-oxime was dissolved in 2 mL methanol, then 37 mg (0.15 mmol) of nickel(II)chloride hexahydrate and 21 mg (0.56 mmol) of sodium borohydride were slowly added. The reaction mixture was stirred overnight at RT and then purified by chromatography (reversed phase).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916589B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-3ccc45aa815c4eaa9de64efc9b27ebdf |
| Source note | uspto-grants-2014_12 |