HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Pyrimidine-5-carboxylic acid{1-[4-(4-bromo-2-chloro-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 4-(4-Bromo-2-chloro-phenoxy)-benzylamine | HCID 28966390 | — |
| Reactant | 1-[(Pyrimidine-5-carbonyl)-amino]cyclopropanecarboxylic acid | HCID 59496291 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Pyrimidine-5-carboxylic acid{1-[4-(4-bromo-2-chloro-phenoxy)-benzylcarbamoyl]-cyclopropyl}-amide | HCID 58487821 | — |
Reaction Steps
7 μL (0.05 mmol) of triethylamine and 8.4 mg (0.03 mmol) of TBTU were added to a solution of 5.4 mg (0.03 mmol) of 1-[(pyrimidin-5-carbonyl)-amino]-cyclo-propanecarboxylic acid (from 1b) in 1 mL DMF and stirred for 5 min at RT. Then 8 mg (0.03 mmol) of 4-(4-bromo-2-chloro-phenoxy)-benzylamine was added and the mixture was stirred overnight at ambient temperature. The reaction mixture was purified by chromatography (reversed phase).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916589B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-3831e996fe214dc09f18e3f64f0b9e4a |
| Source note | uspto-grants-2014_12 |