4-Methoxy-1-(phenylmethoxy)-2-(trifluoromethyl)benzene → 4-Methoxy-2-(trifluoromethyl)phenol

Participants

Reaction Steps

30 g (106.28 mmol) of 1-benzyloxy-4-methoxy-2-trifluoromethyl-benzene were dissolved in 60 mL ethyl acetate and then combined with 3 g palladium/C 10%. The mixture was shaken at RT and 50 psi hydrogen pressure for 4 h. The reaction mixture was suction filtered through Celite and the filtrate was evaporated down. The residue was purified by chromatography (silica gel, petroleum ether/ethyl acetate).

Provenance & Evidence