HCID 66790483, compound → HCID 58487879, compound

HRID 1406372Notes

Reaction equation

HRID 1406372 reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([O:7][C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][CH:9]=2)=[C:5]([C:18]([F:21])([F:20])[F:19])[CH:4]=1.[H][H]>N.[Ni]>[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([O:7][C:8]2[CH:15]=[CH:14][C:11]([CH2:12][NH2:13])=[CH:10][CH:9]=2)=[C:5]([C:18]([F:19])([F:20])[F:21])[CH:4]=1

Participants

5

Reactant 2

HCID 66790483HCID 66790483, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58487879HCID 58487879, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 222AmmoniaSolvent

Procedure

2.53 g (8.63 mmol) of 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzonitrile (from 82c) were dissolved in 100 ml 7M methanolic ammonia, then combined with 250 mg Raney nickel. The mixture was shaken at RT and 50 psi hydrogen pressure for 3 h. The catalyst was removed by suction filtering and the filtrate was evaporated down.

Workup

  1. customThe catalyst was removed by suction
  2. filtrationfiltering
  3. customthe filtrate was evaporated down

Sources & evidence

ORD record
ord-3fb22dc113fe4bf98a4641eae6362c58
Source dataset
uspto-grants-2014_12
Patent number
US08916589B2

Reaction notes

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