HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 25231884, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl-1,2-oxazole-4-carboxylic acid | HCID 4589692 | — |
| Reactant | HCID 67448480 | HCID 67448480 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 25231884 | HCID 25231884 | — |
Reaction Steps
37 μL (0.26 mmol) of triethylamine and 84.4 mg (0.26 mmol) of TBTU were added to a solution of 33.4 mg (0.26 mmol) of 3-methylisoxazole-4-carboxylic acid in 5 mL DMF and the mixture was stirred for 10 min at RT. Then 100 mg (0.26 mmol) of 1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide (from 85a) was added and the mixture was stirred for 4 h at ambient temperature and overnight at 40° C. The reaction mixture was purified by chromatography (reversed phase).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916589B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-018ac5029cbe47ee81c19bdecaa96f90 |
| Source note | uspto-grants-2014_12 |