HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → N-{1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}malonic acid monoamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-{1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}-malonic acid monoamide monoethylester | HCID 25231885 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-{1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}malonic acid monoamide | HCID 25232061 | — |
Reaction Steps
33 mg (0.067 mmol) of N-{1-[4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylcarbamoyl]-cyclopropyl}-malonic acid monoamide monoethylester (from 109a) was stirred for 1 h at RT together with 1 mL sodium hydroxide solution 1M in 20 mL THF. The reaction mixture was evaporated down and the residue was purified by chromatography (reversed phase).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916589B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-5c8c22ef40da46a58b7a6586cf3c66d1 |
| Source note | uspto-grants-2014_12 |