HCID 66792166, compound → HCID 58487847, compound

Participants

Reaction Steps

A solution of 70 mg (0.14 mmol) of pyrimidine-5-carboxylic acid(1-{4-[4-(1-hydroxyethyl)-2-trifluoromethyl-phenoxy]-benzylcarbamoyl}-cyclopropyl)amide (product from Example 153) in 10 mL dichloromethane was combined with 300 mg (3.5 mmol) of manganese dioxide and stirred for three days at ambient temperature. The mixture was then filtered and evaporated down. The crude product thus obtained was purified by chromatography (reversed phase HPLC).

Provenance & Evidence