反应详情

1-(4-Methoxy-benzyl)-4-nitro-1H-pyrazole (240 mg, 1.03 mmol) was stirred in ethanol (10 mL) and the flask was evacuated and then flushed with nitrogen. Platinum, sulfided, 5 wt. % on carbon, reduced, dry (10 mg, catalytic amount) was added and after two vacuum/H2 cycles to replace the nitrogen inside with hydrogen, the mixture was shaken for 18 hours under ordinary hydrogen pressure (1 atm). The reaction mixture was filtered and the filtrate was concentrated in vacuo to yield a red oil, which was used without further purification, 168 mg, 81%.

1. customthe flask was evacuated
2. customflushed with nitrogen
3. customdry (10 mg, catalytic amount)
4. additionwas added
5. filtrationThe reaction mixture was filtered
6. concentrationthe filtrate was concentrated in vacuo
7. customto yield a red oil, which
8. customwas used without further purification, 168 mg, 81%