HRID1406394

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID28373987

未命名化合物

结构：CC(C)(C)OC(=O)n1c(-c2cc(C(=O)O)cn(COCC[Si](C)(C)C)c2=O)cc2ccccc21

HCID58117309

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(Cn2cc(NC(=O)c3cc(-c4cc5ccccc5n4C(=O)OC(C)(C)C)c(=O)n(COCC[Si](C)(C)C)c3)cn2)cc1

HCID66853095

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the experimental used in Example 1, Step 4 using intermediate (1c) and 1-(4-methoxy-benzyl)-1H-pyrazol-4-ylamine. After the usual aqueous work up, the resultant crude product was purified by flash chromatography on SiO2 eluting with hexane—50% ethyl acetate/hexane. This afforded the title compound as a pink solid, 180 mg, 50%.

WORKUP

后处理

customThe title compound was prepared
customAfter the usual aqueous work up, the resultant crude product was purified by flash chromatography on SiO2 eluting with hexane—50% ethyl acetate/hexane

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b52b00bce84a48cc8a84483bb3b9cc2e
来源数据集: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08916591B2
来源说明: uspto-grants-2014_12

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[C:9]1[C:17]1[C:18](=[O:34])[N:19]([CH2:26][O:27][CH2:28][CH2:29][Si:30]([CH3:33])([CH3:32])[CH3:31])[CH:20]=[C:21]([C:23]([OH:25])=O)[CH:22]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:35][O:36][C:37]1[CH:49]=[CH:48][C:40]([CH2:41][N:42]2[CH:46]=[C:45]([NH2:47])[CH:44]=[N:43]2)=[CH:39][CH:38]=1>>[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[C:9]1[C:17]1[C:18](=[O:34])[N:19]([CH2:26][O:27][CH2:28][CH2:29][Si:30]([CH3:32])([CH3:33])[CH3:31])[CH:20]=[C:21]([C:23](=[O:25])[NH:47][C:45]2[CH:44]=[N:43][N:42]([CH2:41][C:40]3[CH:48]=[CH:49][C:37]([O:36][CH3:35])=[CH:38][CH:39]=3)[CH:46]=2)[CH:22]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]