HCID 58117230, compound → HCID 66854965, compound

HRID 1406427Notes

Reaction equation

HRID 1406427 reaction equation
C(OC([N:8]1[C:16]2[C:11](=[CH:12][C:13]([C:17](C)(C)O[SiH2]C(C)(C)C)=[CH:14][CH:15]=2)[CH:10]=[C:9]1[C:26]1[C:27](=[O:41])[N:28](COCC[Si](C)(C)C)[CH:29]=[C:30]([NH2:32])[CH:31]=1)=O)(C)(C)C.[C:42]1([C@@H:48]([N:50]2[CH:54]=[C:53]([C:55](Cl)=[O:56])[CH:52]=[N:51]2)[CH3:49])[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1>>[O:41]=[C:27]1[NH:28][CH:29]=[C:30]([NH:32][C:55]([C:53]2[CH:52]=[N:51][N:50]([C@H:48]([C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=3)[CH3:49])[CH:54]=2)=[O:56])[CH:31]=[C:26]1[C:9]1[NH:8][C:16]2[C:11]([CH:10]=1)=[CH:12][C:13]([CH2:17][N:28]1[CH2:29][CH2:30][CH2:31][CH2:26][CH2:27]1)=[CH:14][CH:15]=2

Participants

3

Reactant 2

HCID 58117230HCID 58117230, compoundHCID 131732190HCID 131732190, compound

Product 1

HCID 66854965HCID 66854965, compound

Procedure

The title compound was prepared by the route outlined in Scheme 8, following the same experimental procedures as for Example 37, reacting intermediate (8d), 2-[5-Amino-2-oxo-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydro-pyridin-3-yl]-5-(tert-butyl-dimethyl-silanyloxymethyl)-indole-1-carboxylic acid tert-butyl with intermediate (6h), 1-((S)-1-Phenyl-ethyl)-1H-pyrazole-4-carbonyl chloride in the coupling step as described for Example 160.

Sources & evidence

ORD record
ord-24cdfb9a613b4194a6953a75aa41292d
Source dataset
uspto-grants-2014_12
Patent number
US08916591B2

Reaction notes

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