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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1406451Generated: October 30, 2026

1,3-Dichloro-2-isothiocyanatobenzene → Ethyl 5-(3-(2,6-dichlorophenyl)thioureido)-2-fluoro-4-(methylamino)benzoate

https://huagongshe.com/reaction/1406451

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-Dichloro-2-isothiocyanatobenzeneHCID 123239—
Reactant5-Amino-2-fluoro-4-methylamino-benzoic acid ethyl esterHCID 67230046—
SolventMethanolHCID 887—
SolventAcetonitrileHCID 6342—
ProductEthyl 5-(3-(2,6-dichlorophenyl)thioureido)-2-fluoro-4-(methylamino)benzoateHCID 86660379—

Reaction Steps

Prepared analogously to example 131d from 5-amino-2-fluoro-4-methylamino-benzoic acid ethyl ester and 1,3-dichloro-2-isothiocyanato-benzene in methanol and acetonitrile.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08916599B2
Source datasetuspto-grants-2014_12
ORD IDord-5c1cc299f09b4d5aabc5acb1eed44855
Source noteuspto-grants-2014_12