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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1406458Generated: October 30, 2026

Ethyl 2-fluoro-4-(methylamino)-5-nitrobenzoate → 5-Amino-2-fluoro-4-methylamino-benzoic acid ethyl ester

https://huagongshe.com/reaction/1406458

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 2-fluoro-4-(methylamino)-5-nitrobenzoateHCID 59529818—
CatalystNickelHCID 935—
SolventTetrahydrofuranHCID 8028—
Product5-Amino-2-fluoro-4-methylamino-benzoic acid ethyl esterHCID 67230046—

Reaction Steps

Prepared analogously to example 156c from 2-fluoro-4-methylamino-5-nitro-benzoic acid ethyl ester and Raney nickel in THF.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08916599B2
Source datasetuspto-grants-2014_12
ORD IDord-2d6f92105b9f49c19d96ab166cffde0c
Source noteuspto-grants-2014_12