HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Methanesulfonate → Methyl 2-methoxy-4-(N-methylacetamido)-5-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Methanesulfonate | HCID 4156 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 4-acetamido-2-methoxy-5-nitrobenzoate | HCID 77723 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2-methoxy-4-(N-methylacetamido)-5-nitrobenzoate | HCID 10379023 | — |
Reaction Steps
A mixture of 4-acetylamino-2-methoxy-5-nitro-benzoic acid methyl ester (4.0 g, 14.9 mmol), methanesulfonic acid methyl ester (1.3 mL, 15.4 mmol) and K2CO3 (4.0 g, 28.9 mmol) in 40 mL DMF was stirred overnight at ambient temperature. The mixture was poured onto ice water and diluted with dichloromethane. The organic phase was separated, dried and concentrated i.vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916599B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-ac114fa1c26e41eab30bb48ba4469019 |
| Source note | uspto-grants-2014_12 |