Nitric Acid → 4-Acetamido-2-fluoro-5-nitrobenzoic acid

HRID 1406467Notes

Reaction equation

HRID 1406467 reaction equation

[C:1]([NH:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([F:14])[CH:6]=1)(=[O:3])[CH3:2].S(=O)(=O)(O)O.[N+:20]([O-])([OH:22])=[O:21]>>[C:1]([NH:4][C:5]1[C:13]([N+:20]([O-:22])=[O:21])=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([F:14])[CH:6]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 944Nitric Acid

HCID 1118Sulfuric Acid

HCID 130413704-Acetamido-2-fluorobenzoic acid

Product 1

HCID 672303024-Acetamido-2-fluoro-5-nitrobenzoic acid

Procedure

Prepared analogously to example 83b from 4-acetylamino-2-fluoro-benzoic acid, conc. sulphuric acid and conc. nitric acid.

Sources & evidence

ORD record: ord-555f893915514bd6a31ac1cded01128b
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08916599B2

Reaction notes

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