HCID 91354783, compound → HCID 67232750, compound

Participants

Reaction Steps

A solution of the product obtained at 142f (320 mg, 1.0 mmol) in 20 mL THF was combined with Raney nickel (70 mg) and hydrogenated in a Parr apparatus at ambient temperature for 1.5 days at 3 bar hydrogen pressure. Then the mixture is filtered and concentrated i.vac. The residue is purified by chromatography on RP-HPLC (stable bond C18, 5 μm). The mixture was concentrated i.vac., taken up in water and treated with K2CO3. The aq. phase is diluted with ethyl acetate. The organic phase is dried, filtered and concentrated i.vac.

Provenance & Evidence