Nitric Acid → 4-Acetamido-2-fluoro-5-nitrobenzoic acid

HRID 1406476Notes

Reaction equation

HRID 1406476 reaction equation
[C:1]([NH:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([F:14])[CH:6]=1)(=[O:3])[CH3:2].S(=O)(=O)(O)O.[N+:20]([O-])([OH:22])=[O:21]>>[C:1]([NH:4][C:5]1[C:13]([N+:20]([O-:22])=[O:21])=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([F:14])[CH:6]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 130413704-Acetamido-2-fluorobenzoic acid

Product 1

HCID 672303024-Acetamido-2-fluoro-5-nitrobenzoic acid

Procedure

Prepared analogously to example 83b from 4-acetylamino-2-fluoro-benzoic acid, conc. sulphuric acid and conc. nitric acid

Sources & evidence

ORD record
ord-36182300ec6c4c2ea7d6cc614c5a4986
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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