Methylamine → Ethyl 2-fluoro-4-(methylamino)-5-nitrobenzoate

Participants

Reaction Steps

A solution of the product obtained at 156a (2.50 g, 10.8 mmol) in 20 mL THF was cooled. 2 M methylamine (solution in THF) (11.5 mL, 23.0 mmol) was added. The mixture was allowed to stir at ambient temperature for 15 min. The mixture was concentrated i.vac. The residue was taken up in water and dichloromethane. The aq. phase was washed with dichloromethane. The combined organic phases were dried and concentrated i.vac. The residue was taken up in ethanol, filtered and washed with ethanol.

Provenance & Evidence