Sodium Hydroxide → HCID 67230051, compound

HRID 1406485Notes

Reaction equation

HRID 1406485 reaction equation
C([O:3][C:4]([C:6]1[CH:24]=[CH:23][C:9]2[N:10]([CH3:22])[C:11]([NH:13][C:14]3[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=3[F:21])=[N:12][C:8]=2[CH:7]=1)=[O:5])C.[OH-].[Na+]>C(O)C>[F:21][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]([F:20])[C:14]=1[NH:13][C:11]1[N:10]([CH3:22])[C:9]2[CH:23]=[CH:24][C:6]([C:4]([OH:5])=[O:3])=[CH:7][C:8]=2[N:12]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67231227HCID 67231227, compound

Product 1

HCID 67230051HCID 67230051, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared analogously to example 3b from 2-(2,6-difluoro-phenylamino)-1-methyl-1H-benzimidazole-5-carboxylic acid ethyl ester and NaOH in ethanol.

Sources & evidence

ORD record
ord-5330359ae971499292a430858a87e926
Source dataset
uspto-grants-2014_12
Patent number
US08916599B2

Reaction notes

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