Water → Oxycodone Hydrochloride

Participants

Reaction Conditions

Reaction Steps

Oxycodone base was charged to water (0.63 g per gram of oxycodone base) and ethanol (2.1 g per gram of oxycodone base). The resulting slurry was heated to 60° C. and a 1:1 (v/v) of ethanol-HCl (0.5-0.6 g per gram) of oxycodone base) was added to adjust the pH of the mixture to 2-5, resulting in a solution. The resulting solution was then cooled to ambient (solid precipitated at 40-46° C.) and then to 0-5° C. and filtered. The cake was washed twice with ethanol (1 g oxycodone HCl/1 g EtOH) and then dried at 55° C. under vacuum. The HPLC and ABUK levels are shown below.

Provenance & Evidence