Hydrochloric Acid → HCID 90411281, compound

Participants

Reaction Steps

Then, 50.01 g of 2,6-difluoro-4-(4-propylphenyl)benzaldehyde and 7 mL g of water were dissolved in 35 mL of ethanol, the resultant solution was cooled with ice, and 2.18 g of sodium tetrahydroborate was slowly added to the solution. After stirring at room temperature for 2 hours, 10% hydrochloric acid was added until the reaction system became acidic, followed by stirring for 1 hour. Then, toluene was added to separate an organic layer, an aqueous layer was subjected to extraction with toluene, and the toluene extract was combined with the organic layer. The resultant mixture was washed with saturated brine and dried by adding sodium sulfate. Then, the solvent was distilled off under reduced pressure, and the residue was recrystallized from ethanol to yield 48.02 g of 2,6-difluoro-4-(4-propylphenyl)benzyl alcohol.

Provenance & Evidence