Hydrochloric Acid → (3R,6S)-6-(1,2,4-oxadiazol-3-yl)piperidin-3-yl(benzyloxy)carbamic chloride

Participants

Reaction Steps

A mixture of (2S,5R)-tert-butyl 5-(benzyloxy(chlorocarbonyl)amino)-2-(1,2,4-oxadiazol-3-yl)piperidine-1-carboxylate (1.6 g), and 4 N HCl in dioxane (18 mL), was stirred at rt for 2 hrs. The solvent was then removed under vacuum to give (3R,6S)-6-(1,2,4-oxadiazol-3-yl)piperidin-3-yl(benzyloxy)carbamic chloride (1.4 g) as a white solid, which was used directly in the next step. ESI-MS (EI+, m/z): 301.0.

Provenance & Evidence