Dimethylformamide dimethyl acetal → HCID 178484349, compound

Participants

Reaction Steps

Dimethoxy-N,N-dimethylmethanamine (0.97 mL, 7 mmol) was added to a solution of (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carboxamide (1.38 g, 5 mmol) in 1,4-dioxane (20 mL) at rt. The mixture was stiffed at 45-50° C. for 2 hrs under vacuum to remove the methanol formed during the reaction. Then, the reaction mixture was concentrated under vacuum, and the residue was washed with Et2O (2×) and dried to give (2S,5R,Z)-6-(benzyloxy)-N-((dimethylamino)methylene)-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carboxamide (1.33 g, 80%) as a white solid. (ESI-MS (EI+, 331, m/z): [M+H]+.

Provenance & Evidence