反应详情

温度

105 °C

To 2-(3-hydroxyphenyl)quinazolin-4(3H)-one (11.0 g, 45.98 mmole) was added pyridine (16.06 mL, 15.71 g, 0.199 mmole) followed by addition of acetic anhydride (145 mL) and the reaction mixture was heated to 105° C. and stirred for 3.5 h. The reaction mixture was cooled to ambient temperature and then poured onto ice-water (800 mL) and stirred for 2 h. The solid was then filtered and washed with water, ethanol, ether and finally hexane and dried for several hours under high vacuum to give 3-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl acetate. (8.4 g, mmol, 65%).

1. temperatureThe reaction mixture was cooled to ambient temperature
2. additionpoured onto ice-water (800 mL)
3. stirringstirred for 2 h
4. filtrationThe solid was then filtered
5. washwashed with water, ethanol, ether and finally hexane
6. customdried for several hours under high vacuum