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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1407039Generated: October 29, 2026

Trifluoroacetic acid → HCID 86691673, compound

https://huagongshe.com/reaction/1407039

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 86691674HCID 86691674—
SolventDichloromethaneHCID 6344—
ProductHCID 86691673HCID 8669167395.4%

Reaction Steps

To a solution of tert-butyl 3-(1-(4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzamido)-2-methoxy-2-oxoethyl)piperidine-1-carboxylate (85 mg) in DCM (5 mL) was added TFA (0.357 mL). The mixture was stirred at room temperature for 4 hours. All the solvents were removed under vacuum to give methyl 2-(4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzamido)-2-(piperidin-3-yl)acetate (70 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08916702B2
Source datasetuspto-grants-2014_12
ORD IDord-e4f96f2fea0142f2876e0105e63c15e0
Source noteuspto-grants-2014_12