HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → methyl O-benzyl-N-(tert-butoxycarbonyl)homoserinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | O-Benzyl-N-(tert-butoxycarbonyl)-L-homoserine | HCID 15058464 | — |
| Solvent | Benzene methanol | HCID 21927730 | — |
| Product | methyl O-benzyl-N-(tert-butoxycarbonyl)homoserinate | HCID 54564501 | — |
Reaction Steps
To O-benzyl-N-(tert-butoxycarbonyl)homoserine (5.8 g, 18.9 mmol) in 20% methanol/benzene (72 mL) is added 2M trimethylsilyldiazomethane in hexane (12.3 mL, 24.5 mmol), and the reaction stirred at room temperature 1.5 h. The solution is concentrated under reduced pressure to give the title compound in pure form. ESI MS m/z 324.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727997B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-92306b3288f94584930245ab3ab8e0d5 |
| Source note | uspto-grants-2010_06 |