HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1407970Generated: October 29, 2026
3-(Trifluoromethyl)phenol → 4-(2-Nitro-5-(piperidin-1-yl)phenyl)-6-(3-(trifluoromethyl)phenoxy)pyrimidine
https://huagongshe.com/reaction/1407970
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Chloro-6-(2-nitro-5-(piperidin-1-yl)phenyl)pyrimidine | HCID 86705928 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(2-Nitro-5-(piperidin-1-yl)phenyl)-6-(3-(trifluoromethyl)phenoxy)pyrimidine | HCID 66586827 | — |
Reaction Steps
To a solution of 160 mg of 3-(trifluoromethyl)phenol in 2 mL of DMF was added 104 mg of potassium carbonate and 160 mg of intermediate 3.1b. After stirring overnight at 50° C. the reaction mixture was partitioned between water and ethyl acetate. The organic extracts were washed with brine and dried (Na2SO4). The solvent was evaporated to give a yellow syrup that was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08916569B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-0803414866fc45218d75a5d0e1b109a0 |
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| Source note | uspto-grants-2014_12 |
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