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HRID 1407996作成日：2026年10月25日

Methyl(2-(morpholin-4-yl)ethyl)amine → N1-methyl-N1-(2-morpholinoethyl)-N3-(4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)isophthalamide

https://huagongshe.com/reaction/1407996

反応式

関与物質

役割名称HCID仕込み量
反応物Methyl(2-(morpholin-4-yl)ethyl)amineHCID 14979282—
反応物3-((2-(4-((3-(Trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzoic acidHCID 66586784—
反応物N1-Ethyl-N1-(2-morpholinoethyl)-N3-(4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)isophthalamideHCID 69631832—
生成物N1-methyl-N1-(2-morpholinoethyl)-N3-(4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)isophthalamideHCID 69631879—

反応手順

This compound was prepared by coupling N-methyl-2-morpholinoethylamine to 3-((4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)-carbamoyl)benzoic acid 4.1e, using the procedure described for the preparation of N1-ethyl-N1-(2-morpholinoethyl)-N3-(4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)-carbamoyl)pyridin-2-yl)phenyl)isophthalamide 4.8. MS (ES, m/z): 743 [M+H]+

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08916569B2
出典データセットuspto-grants-2014_12
ORD IDord-1c4850f71fc74ad9a76348d0356bd1ca
出典メモuspto-grants-2014_12