2-(Methylamino)ethanol → HCID 86705934, compound

HRID 1407998Notes

Reaction equation

HRID 1407998 reaction equation
C[O:2][CH2:3][CH2:4][N:5]([CH3:53])[CH2:6][CH2:7][N:8]([CH3:52])[C:9](=[O:51])[C:10]1[CH:50]=[CH:49][CH:48]=[C:12]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)=[CH:18][C:17]=2[C:28]2[CH:33]=[C:32]([C:34](=[O:47])[NH:35][CH2:36][C:37]3[CH:42]=[CH:41][CH:40]=[C:39]([C:43]([F:46])([F:45])[F:44])[CH:38]=3)[CH:31]=[CH:30][N:29]=2)=[O:14])[CH:11]=1.CNCCO>>[OH:2][CH2:3][CH2:4][N:5]([CH3:53])[CH2:6][CH2:7][N:8]([CH3:52])[C:9](=[O:51])[C:10]1[CH:50]=[CH:49][CH:48]=[C:12]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)=[CH:18][C:17]=2[C:28]2[CH:33]=[C:32]([C:34](=[O:47])[NH:35][CH2:36][C:37]3[CH:42]=[CH:41][CH:40]=[C:39]([C:43]([F:44])([F:46])[F:45])[CH:38]=3)[CH:31]=[CH:30][N:29]=2)=[O:14])[CH:11]=1

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 86705935HCID 86705935, compound

Product 1

HCID 86705934HCID 86705934, compound

Procedure

This compound was prepared by the procedure described for the preparation of N1-(2-((2-methoxyethyl)(methyl)amino)ethyl)-N1-methyl-N3-(4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)isophthalamide 4.20.2, using 2-(methylamino) ethanol in place of N-methyl-2-(methoxyethyl)amine. MS (ES, m/z): 717 [M+H]+.

Workup

  1. customThis compound was prepared by the procedure

Sources & evidence

ORD record
ord-b44bd98cea88447987901e61db04cdb8
Source dataset
uspto-grants-2014_12
Patent number
US08916569B2

Reaction notes

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