1-Acetylpiperazine → HCID 66588078, compound

HRID 1408112Notes

Reaction equation

C(N1CCN([CH2:10][C:11]2[N:16]=[C:15]([C:17]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([N:26]4[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]4)=[CH:22][C:21]=3[C:32]3[CH:37]=[C:36]([C:38](=[O:51])[NH:39][CH2:40][C:41]4[CH:46]=[CH:45][CH:44]=[C:43]([C:47]([F:50])([F:49])[F:48])[CH:42]=4)[CH:35]=[CH:34][N:33]=3)=[O:18])[CH:14]=[CH:13][CH:12]=2)CC1)(=O)C.[N:52]1([C:59]([O:61][C:62]([CH3:65])([CH3:64])[CH3:63])=[O:60])[CH2:58][CH2:57][CH2:56][NH:55][CH2:54][CH2:53]1.N1(C(=O)C)CCNCC1>>[N:26]1([C:23]2[CH:24]=[CH:25][C:20]([NH:19][C:17]([C:15]3[N:16]=[C:11]([CH2:10][N:55]4[CH2:56][CH2:57][CH2:58][N:52]([C:59]([O:61][C:62]([CH3:65])([CH3:64])[CH3:63])=[O:60])[CH2:53][CH2:54]4)[CH:12]=[CH:13][CH:14]=3)=[O:18])=[C:21]([C:32]3[CH:37]=[C:36]([C:38](=[O:51])[NH:39][CH2:40][C:41]4[CH:46]=[CH:45][CH:44]=[C:43]([C:47]([F:48])([F:49])[F:50])[CH:42]=4)[CH:35]=[CH:34][N:33]=3)[CH:22]=2)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

Reactant 3

HCID 837951-Acetylpiperazine

HCID 2756058Tert-butyl 1,4-diazepane-1-carboxylate

HCID 66586764HCID 66586764, compound

Product 1

HCID 66588078HCID 66588078, compound

Procedure

This compound was prepared using the procedure described for the preparation of 6-((4-acetylpiperazin-1-yl)methyl)-N-(4-(piperidin-1-yl)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)picolinamide 58, substituting tert-butyl 1,4-diazepane-1-carboxylate for -(piperazin-1-yl)ethanone.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-8f482c469cb247f481943a38095f4926
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08916569B2

Reaction notes

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