1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → tert-butyl 3-(3-((2-(4-((4-(1H-pyrazol-1-yl)benzyl)carbamoyl)pyridin-2-yl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzylthio)propanoate

HRID 1408161Notes

Reaction equation

HRID 1408161 reaction equation
[C:1]([O:5][C:6](=[O:41])[CH2:7][CH2:8][S:9][CH2:10][C:11]1[CH:12]=[C:13]([CH:38]=[CH:39][CH:40]=1)[C:14]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)=[CH:19][C:18]=1[C:29]1[CH:30]=[C:31]([CH:35]=[CH:36][N:37]=1)[C:32](O)=[O:33])=[O:15])([CH3:4])([CH3:3])[CH3:2].[N:42]1([C:47]2[CH:52]=[CH:51][C:50]([CH2:53][NH2:54])=[CH:49][CH:48]=2)[CH:46]=[CH:45][CH:44]=[N:43]1.CCN=C=NCCCN(C)C.Cl>CN(C)C1C=CN=CC=1.ClCCl>[N:42]1([C:47]2[CH:52]=[CH:51][C:50]([CH2:53][NH:54][C:32]([C:31]3[CH:35]=[CH:36][N:37]=[C:29]([C:18]4[CH:19]=[C:20]([N:23]5[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]5)[CH:21]=[CH:22][C:17]=4[NH:16][C:14]([C:13]4[CH:12]=[C:11]([CH:40]=[CH:39][CH:38]=4)[CH2:10][S:9][CH2:8][CH2:7][C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:41])=[O:15])[CH:30]=3)=[O:33])=[CH:49][CH:48]=2)[CH:46]=[CH:45][CH:44]=[N:43]1

Participants

6

Reactant 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27764834-Pyrazol-1-YL-benzylamineHCID 665867222-(2-(3-((3-Tert-butoxy-3-oxopropylthio)methyl)benzamido)-5-(piperidin-1-yl)phenyl)isonicotinic acid

Product 1

HCID 66587472tert-butyl 3-(3-((2-(4-((4-(1H-pyrazol-1-yl)benzyl)carbamoyl)pyridin-2-yl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzylthio)propanoateYield 83%

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

Into a 50-mL 3-necked round-bottom flask, was placed 2-(2-(3-((3-tert-butoxy-3-oxopropylthio) methyl)benzamido)-5-(piperidin-1-yl)phenyl)isonicotinic acid (125 mg, 0.22 mmol, 1.00 equiv), (4-(1H-pyrazol-1-yl)phenyl)methanamine (41 mg, 0.24 mmol, 1.10 equiv), EDC.HCl (62 mg, 0.32 mmol, 1.50 equiv), 4-dimethylaminopyridine (40 mg, 0.33 mmol, 1.51 equiv), and dichloromethane (15 mL). The resulting solution was stirred overnight at room temperature. The resulting solution was extracted with 40 mL of dichloromethane and the organic layers combined. The resulting mixture was washed with 2×15 mL of H2O. The mixture was dried over anhydrous sodium sulfate and concentrated under vacuum. The product was obtained as 0.132 g (83%) of a yellow crude solid.

Workup

  1. customInto a 50-mL 3-necked round-bottom flask, was placed
  2. extractionThe resulting solution was extracted with 40 mL of dichloromethane
  3. washThe resulting mixture was washed with 2×15 mL of H2O
  4. dry with materialThe mixture was dried over anhydrous sodium sulfate
  5. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-d072b9e8810e463796616809cb70df52
Source dataset
uspto-grants-2014_12
Patent number
US08916569B2

Reaction notes

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