Dimethylamine → 3-(3-(4-(Dimethylamino)-2-(4-(3-(trifluoromethyl)benzylcarbamoyl)pyridin-2-yl)phenylcarbamoyl)benzylthio)propanoic acid

HRID 1408174Notes

Reaction equation

HRID 1408174 reaction equation
[CH2:1]([N:4]([CH2:47]CC)[C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[CH:15]=[C:16]([CH:24]=[CH:25][CH:26]=2)[CH2:17][S:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[O:13])=[C:7]([C:27]2[CH:32]=[C:31]([C:33](=[O:46])[NH:34][CH2:35][C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([C:42]([F:45])([F:44])[F:43])[CH:37]=3)[CH:30]=[CH:29][N:28]=2)[CH:6]=1)CC.CNC>CS(C)=O>[CH3:47][N:4]([CH3:1])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[CH:15]=[C:16]([CH:24]=[CH:25][CH:26]=2)[CH2:17][S:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[O:13])=[C:7]([C:27]2[CH:32]=[C:31]([C:33](=[O:46])[NH:34][CH2:35][C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([C:42]([F:45])([F:44])[F:43])[CH:37]=3)[CH:30]=[CH:29][N:28]=2)[CH:6]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 665868383-((3-((4-(Dipropylamino)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Product 1

HCID 665881053-(3-(4-(Dimethylamino)-2-(4-(3-(trifluoromethyl)benzylcarbamoyl)pyridin-2-yl)phenylcarbamoyl)benzylthio)propanoic acid

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

This compound was prepared according to the procedure described for the synthesis of 3-((3-((4-(Dipropylamino)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)carbamoyl)benzyl)thio)propanoic acid Example 19, using dimethylamine in place of dipropylamine. (ES, m/z): 637 [M+H]+(300 MHz, DMSO, ppm): 12.10 (s, 1H), 9.53 (t, J=6.0 Hz, 1H), 8.97 (d, J=5.1 Hz, 1H), 8.33 (s, 1H), 8.26 (d, J=8.7 Hz, 1H), 7.85-7.87 (m, 2H), 7.72-7.77 (m, 2H), 7.45-7.69 (m, 5H), 7.35 (s, 1H), 7.09 (d, J=7.8 Hz, 1H), 4.63 (d, J=5.7 Hz, 2H), 3.87 (s, 2H), 3.04 (s, 6H), 2.53-2.64 (m, 4H).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-85422b8f4a09486b8db2cf9c73769b1b
Source dataset
uspto-grants-2014_12
Patent number
US08916569B2

Reaction notes

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