(S)-N-(2-methoxyethyl)piperidine-3-carboxamide → (S)-2-(5-(diethylamino)-2-(3-(3-((2-methoxyethyl)carbamoyl)piperidine-1-carbonyl)benzamido)phenyl)-N-(3-(trifluoromethyl)benzyl)isonicotinamide

HRID 1408196Notes

Reaction equation

HRID 1408196 reaction equation
[CH2:1]([N:3]([CH2:61][CH3:62])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[CH:14]=[C:15]([C:19](=[O:40])[N:20]([CH3:39])CCOCCOCCOCCC(OC(C)(C)C)=O)[CH:16]=[CH:17][CH:18]=2)=[O:12])=[C:6]([C:41]2[CH:46]=[C:45]([C:47](=[O:60])[NH:48][CH2:49][C:50]3[CH:55]=[CH:54][CH:53]=[C:52]([C:56]([F:59])([F:58])[F:57])[CH:51]=3)[CH:44]=[CH:43][N:42]=2)[CH:5]=1)[CH3:2].[CH3:63][O:64][CH2:65][CH2:66][NH:67][C:68]([C@H:70]1[CH2:75][CH2:74][CH2:73]NC1)=[O:69]>>[CH2:1]([N:3]([CH2:61][CH3:62])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:12])[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([N:20]3[CH2:73][CH2:74][CH2:75][C@H:70]([C:68](=[O:69])[NH:67][CH2:66][CH2:65][O:64][CH3:63])[CH2:39]3)=[O:40])[CH:14]=2)=[C:6]([C:41]2[CH:46]=[C:45]([CH:44]=[CH:43][N:42]=2)[C:47]([NH:48][CH2:49][C:50]2[CH:55]=[CH:54][CH:53]=[C:52]([C:56]([F:59])([F:58])[F:57])[CH:51]=2)=[O:60])[CH:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 28162916(S)-N-(2-methoxyethyl)piperidine-3-carboxamideHCID 66586842HCID 66586842, compound

Product 1

HCID 86705968(S)-2-(5-(diethylamino)-2-(3-(3-((2-methoxyethyl)carbamoyl)piperidine-1-carbonyl)benzamido)phenyl)-N-(3-(trifluoromethyl)benzyl)isonicotinamide

Procedure

This compound was prepared according to the procedure described for the synthesis of tert-butyl 1-(3-((4-(diethylamino)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)carbamoyl)phenyl)-2-methyl-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oate Example 188, using (S)—N-(2-methoxyethyl)piperidine-3-carboxamide 4.14a in place of tert-butyl 5,8,11-trioxa-2-azatetradecan-14-oate. MS (ES, m/z): 759.4 [M+H]+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-5d2993b881224fe2870fa19750ae21fe
Source dataset
uspto-grants-2014_12
Patent number
US08916569B2

Reaction notes

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