HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1408208Generated: November 1, 2026
Diisopropylethylamine → (S)-benzyl (2-(2-(2,5,8,11,14,17,20,23-octaoxapentacosan-25-ylcarbamoyl) piperidin-1-yl)ethyl)(methyl)carbamate
https://huagongshe.com/reaction/1408208
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 2,5,8,11,14,17,20,23-Octaoxapentacosan-25-amine | HCID 51340963 | — |
| Reactant | (S)-1-(2-(((benzyloxy)carbonyl) (methyl)amino)ethyl)piperidine-2-carboxylic acid | HCID 66586881 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (S)-benzyl (2-(2-(2,5,8,11,14,17,20,23-octaoxapentacosan-25-ylcarbamoyl) piperidin-1-yl)ethyl)(methyl)carbamate | HCID 86705977 | — |
Reaction Steps
To a mixture of (S)-1-(2-(((benzyloxy)carbonyl)(methyl)amino)ethyl)piperidine-2-carboxylic acid (0.145 mmol, 46.4 mg), 2,5,8,11,14,17,20,23-octaoxapentacosan-25-amine (0.145 mmol, 55.6 mg), DIEA (0.725 mmol, 94 mg) in DMF (0.3 mL) was added HATU (0.16 mmol, 61 mg). The mixture was stirred at 60° C. for 1 h. The crude mixture was used in next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08916569B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-39a76058ecd14d65b8118c7619981c1d |
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| Source note | uspto-grants-2014_12 |
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