HCID 86705997, compound → HCID 86705996, compound

HRID 1408248Notes

Reaction equation

HRID 1408248 reaction equation
[CH2:1]([N:3]([CH2:67][CH3:68])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[CH:14]=[C:15]([CH2:19][CH2:20][CH2:21][O:22][CH2:23][CH2:24][O:25][CH2:26][CH2:27][O:28][CH2:29][CH2:30][O:31][CH2:32][CH2:33][NH:34][S:35]([C:38]3[CH:46]=[CH:45][C:41]([C:42](O)=[O:43])=[CH:40][CH:39]=3)(=[O:37])=[O:36])[CH:16]=[CH:17][CH:18]=2)=[O:12])=[C:6]([C:47]2[CH:52]=[C:51]([C:53](=[O:66])[NH:54][CH2:55][C:56]3[CH:61]=[CH:60][CH:59]=[C:58]([C:62]([F:65])([F:64])[F:63])[CH:57]=3)[CH:50]=[CH:49][N:48]=2)[CH:5]=1)[CH3:2].[CH3:69][O:70][CH2:71][CH2:72][O:73][CH2:74][CH2:75][O:76][CH2:77][CH2:78][O:79][CH2:80][CH2:81][O:82][CH2:83][CH2:84][O:85][CH2:86][CH2:87][O:88][CH2:89][CH2:90][N:91]1[CH2:96][CH2:95][NH:94][CH2:93][C:92]1=[O:97]>>[CH3:69][O:70][CH2:71][CH2:72][O:73][CH2:74][CH2:75][O:76][CH2:77][CH2:78][O:79][CH2:80][CH2:81][O:82][CH2:83][CH2:84][O:85][CH2:86][CH2:87][O:88][CH2:89][CH2:90][N:91]1[CH2:96][CH2:95][N:94]([C:42]([C:41]2[CH:45]=[CH:46][C:38]([S:35]([NH:34][CH2:33][CH2:32][O:31][CH2:30][CH2:29][O:28][CH2:27][CH2:26][O:25][CH2:24][CH2:23][O:22][CH2:21][CH2:20][CH2:19][C:15]3[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=3)[C:11]([NH:10][C:7]3[CH:8]=[CH:9][C:4]([N:3]([CH2:1][CH3:2])[CH2:67][CH3:68])=[CH:5][C:6]=3[C:47]3[CH:52]=[C:51]([CH:50]=[CH:49][N:48]=3)[C:53]([NH:54][CH2:55][C:56]3[CH:61]=[CH:60][CH:59]=[C:58]([C:62]([F:65])([F:64])[F:63])[CH:57]=3)=[O:66])=[O:12])(=[O:37])=[O:36])=[CH:39][CH:40]=2)=[O:43])[CH2:93][C:92]1=[O:97]

Participants

3

Reactant 2

HCID 86705997HCID 86705997, compoundHCID 86705998HCID 86705998, compound

Product 1

HCID 86705996HCID 86705996, compound

Procedure

This compound was prepared from 4-(N-(15-(3-(4-(diethylamino)-2-(4-(3-(trifluoromethyl)benzylcarbamoyl)pyridin-2-yl)phenylcarbamoyl)phenyl)-3,6,9,12-tetraoxapentadecyl)sulfamoyl)benzoic acid 272a by following the procedure described in Example 272 using 1-(2,5,8,11,14,17,20-heptaoxadocosan-22-yl)piperazin-2-one 135c.5 as the amine component in this coupling. MS (ES, m/z) 1368.4 [M+H]+.

Sources & evidence

ORD record
ord-c13475d5c05545e9bf4e1d7d6e55669b
Source dataset
uspto-grants-2014_12
Patent number
US08916569B2

Reaction notes

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