Urea → Thiazolo[4,5-d]pyrimidine-5,7-diol

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 4-aminothiazole-5-carboxylate (1.0 eq.) and urea (5 eq.) was heated at 190° C. for 2 hours. The hot reaction mixture was poured onto sodium hydroxide solution and any insoluble material was removed by filtration. The mixture was then acidified (HCl, 2N) to yield thiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione as a white precipitate, which was collected by filtration and air dried.

Provenance & Evidence