Morpholine → 5-Chloro-7-(morpholin-4-yl)[1,3]thiazolo[4,5-d]pyrimidine

Participants

Reaction Steps

A mixture of 5,7-dichlorothiazolo[4,5-d]pyrimidine (1.0 eq.), morpholine (2.2 eq.) and MeOH was stirred at room temperature for 1 h. The reaction mixture was then filtered, washed with water and MeOH, to yield 4-(5-chlorothiazolo[4,5-d]pyrimidin-7-yl)morpholine as a white solid (100%).

Provenance & Evidence