Imidazole → HCID 58508014, compound

Participants

Reaction Conditions

Reaction Steps

3-(7-morpholinothiazolo[4,5-d]pyrimidin-5-yl)phenol (1.0 eq.) was dissolved in DMF (5 ml). To this imidazole (8.0 eq.) and TBDMSCl (3.5 eq.) were added and the mixture was heated at 70° C. for 5 h. DMF was evaporated under reduced pressure and purification by flash chromatography (hexane:ethyl acetate, gradient from 100%-50% hexane in EtOAc) yielded the title compound as a white solid.

Provenance & Evidence