tert-Butyl N-(2-bromoethyl)carbamate → HCID 58507731, compound

Participants

Reaction Conditions

Reaction Steps

4-(2-(3-(tert-butyldimethylsilyloxy)phenyl)thieno[3,2-d]pyrimidin-4-yl)morpholine (166 mg, 388 μmol, 1.0 eq.) was solved with dry THF (3 ml) under room temperature and added to a round-two-neck flask that was heated under vacuum and flushed with nitrogen. The solution was then cooled to −78° C. and n-BuLi (315 μl, 1.6 M solution in hexanes, 1.3 eq.) was added dropwise. After stirring for 20 min., 2-(boc-amino)ethyl bromide (130 mg, 582 μmol, 1.5 eq.) was added to the reaction mixture and the reaction mixture was stirred at −78° C. for 20 min. and then warmed to room temperature. The reaction mixture was further stirred at room temperature overnight.

Provenance & Evidence