HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 1-Cyclopropyl-4,4,4-trifluorobutane-1,3-dione | HCID 11194673 | — |
| Reactant | Water ethylacetate | HCID 22728543 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole | HCID 7147438 | 98.1% |
Reaction Steps
Intermediate 2 (0.120 g, 0.66 mmol) and hydrazine hydrate (0.04 mL, 0.72 mmol) were dissolved in ethanol (6 mL) and refluxed overnight. Work-up (H2O/AcOEt) after cooling the mixture to RT gave the title compound as a brown solid (0.114 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08921364B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-3fac0e39e93047ddb2cba530d53d8f87 |
| Source note | uspto-grants-2014_12 |