Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-Phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid | HCID 22250323 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 12914838 | HCID 12914838 | — |
Reaction Steps
Intermediate 7 (1.55 g, 6.0 mmol) was dissolved in MeOH (15 ml), cooled to 0° C. and thionyl chloride (1.3 ml, 18.2 mmol) was added. Reaction mixture was heated to 60° C. for overnight. Work up (AcOEt:H2O) followed by evaporation on high vacuum obtained the title compound as an yellow solid. 1H-NMR (δ ppm, CDCl3, 400 MHz): 7.51-7.47 (m, 3H), 7.46-7.41 (m, 2H), 7.50 (s, 1H), 3.82 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08921364B2 |
|---|
| Source dataset | uspto-grants-2014_12 |
|---|
| ORD ID | ord-e4df463d93474b24a17fa8fff1bc8661 |
|---|
| Source note | uspto-grants-2014_12 |
|---|
