Nitric Acid → HCID 67114960, compound

Participants

Reaction Conditions

Reaction Steps

Intermediate 8 (2 g, 7.4 mmol) was dissolved in acetic acid (15 ml), cooled to 0° C. and added nitration mixture (6 ml HNO3 and 6 ml H2SO4) drop-wise. Reaction mixture was heated to 60° C. for overnight. Work up (AcOEt:H2O) and purification on silicagel (60-120 mesh silicagel) using EA and pet ether (3:97) as eluent afforded the title compound (850 mg) as a white solid. 1H-NMR (δ ppm, CDCl3, 400 MHz): 8.37 (d, J 9, 2H), 7.68 (d, J 9, 2H), 7.31 (s, 1H), 3.87 (s, 3H).

Provenance & Evidence