Hydrochloric Acid → 4-Methyl-5-pyrimidinecarboxylic acid

HRID 1408519Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1408519
[CH3:1][C:2]1[C:7]([C:8]([O:10]CC)=[O:9])=[CH:6][N:5]=[CH:4][N:3]=1.[OH-].[Na+].Cl>>[CH3:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=[CH:4][N:3]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13192893Ethyl 4-methylpyrimidine-5-carboxylate

Produkt 1

HCID 149222194-Methyl-5-pyrimidinecarboxylic acidAusbeute 69,4 %

Versuchsvorschrift

Intermediate 52 (2.6 g, 15.64 mmol) dissolved in sodium hydroxide solution (1.88 g, 47 mmol in 4 ml water) and refluxed. The reaction mixture was cooled to rt and acidified with con HCl to obtain the solid. Solid that obtained was filtered and dried to obtain the title compound (1.5 g) as an yellow solid. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 13.5 (bs, 1H), 9.14 (s, 1H), 9.05 (s, 1H), 2.71 (s, 3H).

Aufarbeitung

  1. temperaturerefluxed
  2. customto obtain the solid
  3. customSolid that obtained
  4. filtrationwas filtered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-f57e133516a14f7192f92316610ea844
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08921364B2

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